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Prothrombin Time, Clothing Time, Platelet Concentration and Haematocrit During Labour and Postpartum of Women in Zaria, Northern Nigeria
並列摘要
This study was aimed at studying the influence of labour and parturition on the clotting profiles, platelet concentration and haematocrit and causes of variations of women in Zaria, Northern Nigeria. Pregnancy is a physiologic state t frequently complicated by thrombo-embolism and haemorrhage. Prothrombin Time (PT), Whole blood Clothing Time (CT) Platelet Concentration and haematocrit (PCV) were measured in 50 women in labour and within one (1) hour postpartum and compared with values in aged matched non pregnant controls. The clothing time of 3.32 ± 0.16 min. during labour was significantly lower than values of 5.30 ± 0.19 and 4.56 ± 0.15 min obtained in control and at post partum respectively (p ＜ 0.05). Postpartum haematocrit of 26.10 ± 0.77 and 30.14 ± 0.60% obtained during labour were significantly lower than the PCV of 36.66 ± 0.36% obtained in the control non pregnant subject (p ＜ 0.001, p ＜ 0.05). Prothrombin Time (PT) of 8.30 ± 0.15 sec obtained during labour was significantly lower than values of 9.20 ± 0.29 and 9.40±0.34 sec obtained in controls and postpartum respectively (p ＜ 0.05). Platelet concentration of 214.38 ± 21.0 × 10^9 and 217.50 ± 12.0 × 10^9 /L within 1hr postpartum and durimg labour, respectively were significantly lower than the concentration of 376.47 ± 26.21 × 10^9/L in the control subjects. We conclude that the subjects had features of hyper-coagulation state during labour which reversed within 1hr postpartum and the subjects were anemic postpartum. The CT and PCV were significantly altered postpartum by parity and mode of delivery.