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Chronic Oral Administration of Ethanol Extract of ＂Carica papaya＂ Seeds Does not Affect the Histology of the Cauda Epididymis of Adult Male Wistar Rats
並列摘要
The role of the epididymis in male reproduction has been studied and it is well established that the spermatozoa are produced by the germinal epithelia of seminiferous tubules and are transported to the epididymis for onward transport, maturation and storage. The antifertility property of ＂Carica papaya＂ seed extracts have also been well documented in experimental animals. This study examines the effect of chronic oral administration of ethanol extract of ＂C. papaya＂ on the histology of adult male wistar rats. 15 apparently healthy adult male wistar rats were obtained from the animal house of the Department of Human Anatomy, Ahmadu Bello University Zaria and divided into 3 groups (I, II, III) of 5 each. 100 and 250 mg/kg/day of the extract was orally administered to groups II and III, respectively while group I which served as control received distilled water. The daily administration was carried out for a period of 90 days after which the animals were humanely sacrificed, the epididymis obtained and processed for light microscopy. Microscopic examination of the epididymis showed normal histology in both the control and experimental groups. This study concludes that the oral administration of the extract which has great potential in male fertility control does not affect the histology of the epididymis of adult male wistar rats.