- 期刊
- OpenAccess
Histopathological Comparison of the Effect of Normal Saline and Silver Sulfadiazine on Scorch Healing in Rats
並列摘要
Skin burn is one of the most common complications throughout the world. Silver sulfadiazine (SSD) is used as a choice treatment in many superficial burn wounds. But, some studies have questioned its efficacy. The main objective of this study was to compare the effects of Normal Saline (NS) and SSD on healing of superficial skin burn wounds in rats. Male Wistar rats were randomly assigned in two different groups including treatment and control, with 20 animals each. After sedation, a type II skin burn wound in the shape of a 1-cm diameter circle was created in the dorsum of the rats with boiled water contact. In treatment group, NS and in control group, SSD was used topically for care. Diameter of the wound as well as the hair growing grade was determined on days 3, 7 and 14 post-intervention. In each step of the experiment, histopathological sections were prepared; thereafter reepithelialization and alleviation of inflammation at the healing site of burn wound were assessed. Statistically, the data obtained were compared between the groups. There were no significant differences between the groups regarding the mean diameter of the wound on days 3 and 14 (p = 0.089, p = 0.495). The mean diameter of the wound was significantly lower in treatment (NS) group on day 7 (p＜0.001). There were no significant differences between the groups regarding the mean hair growth score in different stages of the experiment (p = 1, p = 0.647, p = 0.805). Histopathologically, there were no significant difference between these two experimental groups from the view point of reepithelialization and alleviation of inflammation at the healing site of burn wound. The results of this study showed that NS equals with SSD in improvement of superficial skin burn wounds healing in the rats; and after the randomized clinical trials, it can be used in treatment of superficial skin burn wounds in human bodies.