With the rapid development of science-biotechnology, the safety of genetically modified organisms has become some of the most controversial issues in our society. This study aims to review the safety assessment and countermeasures of Genetically Modified (GM) foods. Firstly, the research status and the main contents of GM foods safety assessment are discussed. What's more, the countermeasures of GM foods safety assessment are proposed. This study tries to summarize and discuss the safety assessment of GM foods.