The aim of this study is to explore algal species with anti-bacterial activity against six food-borne pathogens. Among 51 marine algae, "Laurencia okamurae" Yamada and "Dictyopteris undulate" Holmes was elucidated to have a potent anti-bacterial activity against food-borne pathogens. "Laurencia okamurae" Yamada showed the clear zone around agar well on "B. cereus", "S. aureusand L. monocytogenes-spreading" agar plate. "Dictyopteris undulate" Holmes had the anti-bacterial activity against "S. chorelaesuis, B. cereus", "S. aureus" and "L. monocytogenes" on bacterial spreading agar plates. Antibacterial activity of "L. okamurae" Yamada and "D. undulate" Holmes had specifically susceptibility for "B. cereus", "S. aureus" and "L. monocytogenes" and were superior to streptomycin, the authentic antibiotics. It is anticipated that new food preservatives can be explored and developed on the basis of this study.