Bioactivity-guided Isolation and Characterization of Antitumor Active Compound from Marine-derived Fungus Penicillium chrysogenum HGQ6

Lei Guo ； Tao Huang ； Bing Hu ； Cong Wang

《Advance Journal of Food Science and Technology》 10卷5期 (2016/02) Pp. 353-355

並列摘要

To isolate and characterize antitumor active compounds (bioactivity-guided fractionation) from the ethyl acetate extract of fermentation broth of marine-derived fungus Penicillium chrysogenum HGQ6. Following the cytotoxicity against human cancer cell line BGC823, one compound was isolated and purified by silica gel chromatography, Sephadex LH-20 chromatography and preparative high performance liquid chromatography. The isolated compound was elucidated on the basis of extensive spectroscopic data analysis as 5-hydroxymethyl-2- furancarboxaldehyde, which exhibited cytotoxicity against BGC823 cell line with an IC50 value of 0.19 mg/mL. Our present study concluded that, 5-Hydroxymethyl-2-furancarboxaldehyde isolated from marine-derived fungus Penicillium chrysogenum HGQ6 has a certain extent of antitumor potential.

並列關鍵字

Antitumor activity ； isolation and characterization ； marine-derived fungus ； Penicillium chrysogenum HGQ6