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Effect of ＂Peristrophe bicalyculata＂ on Blood Pressure, Kidney and Liver Functions of Two Kidney One Clip (2K1C) Hypertensive Rats
並列摘要
The aqueous, butanolic and methanolic fractions of ＂Peristrophe bicalyculata＂ were accessed for their effect on the arterial blood pressure, liver enzymes and some kidney parameters in hypertensive rats. Forty rats were divided into nine groups of five rats each: control, hypertensive control, Standard (enalapril 3.8 mg/kg), methanolic extract (100 and 200 mg/kg), butanolic extract (100 and 200mg/kg) and aqueous extract (100 and 200mg/kg). All rats, except control group were made hypertensive using the Goldbatt Two Kidney One Clip (2K1C) method. Administration of extracts began four weeks after induction of hypertension, and lasted for two weeks. Blood pressure was determined before inducing hypertension, and then weekly after the induction. Liver and kidney parameters were determined at the end of experiment. Results showed a significant decrease (p＜0.05) in blood pressure of the rats given the standard and all extracts compared to the hypertensive control group. The serum levels of urea and creatinine, as well as alanine aminotranferase (ALT) activity significantly decreased in rats given the standard drug, and all extracts, while the butanolic extract did not have effect on activity of aspartate transaminase and alkaline phosphatase compared to the hypertensive control group. However, the blood pressure and other parameters determined were significantly (p＜0.05) different in rats treated with the aqueous extract, especially at a higher dose (250mg/kg) compared to those given the butanolic and methanolic extracts of the plant. In conclusion, this work has demonstrated the antihypertensive and hepatoprotective effect of Peristrophe bicalyculata, with the aqueous extract being the most effective.