Study of the Effect of Aqueous Extract of Kolanut (Cola nitida) on Gastric Acid Secretion and Ulcer in White Wistar Rats

J. A.Tende ； I. Ezekiel ； S. S. Dare ； A. O. Okpanachi ； S. O. Kemuma ； A. D. T. Goji

《British Journal of Pharmacology and Toxicology》 2卷3期 (2011/08) Pp. 132-134

並列摘要

Generally, increase in the acid output in the body causes ulcer especially peptic ulcer. Duodenal ulcer has worldwide incidence but its incidence varies geographically and even in some country regionally. Duodenal and peptic ulcer diseases are problems of the gastrointestinal tract. Nowadays, drugs are expensive and have many side effects during treatment of any disorders. In this study the aqueous extract of cola nitida was administered to 30 Wistar rats in two phases (gastric acid secretion phase and ulceration phase). The ulcer score and gastric acidity were determined. The highest acid output was obtained with a dose of 7.5 mg/mL and the lowest with a dose of 5.0 mg/mL. However no ulceration was seen with the same doses of cola nitida, this may mean that formation of ulcerations may not be only due to increase acidity or probably the doses used was not enough to cause ulceration. Comparing this with control group gave a significant difference for the gastric acid secretion group, though there was no ulceration formed with the same dose. The result of this study showed that cola nitida induces gastric secretion

並列關鍵字

Caffeine ； cola nitida ； duodenal ； gastric secretion ； peptic ulcer ； xanthine