Determination of Nephrotoxicity and Hepatoxicity of Monosodium Glutamate (MSG) Consumption

H. M. Inuwa ； V. O. Aina ； 2Baba Gabi ； I. Aim ola ； Leehman Ja'afaru

《British Journal of Pharmacology and Toxicology》 2卷3期 (2011/08) Pp. 148-153

並列摘要

Investigations were conducted to determine the Nephrotoxicity and Hepatoxicity of Monosodium Glutamate (MSG). Graded doses of monosodium glutamate were administered orally to Adult Wister rats weighing between (160.7-238.6 g) for 28 days. Liver and Kidney function tests were carried out on the blood serum. Monosodium glutamate elicited an increase in body weight in an ascending fashion from group B to group D though not statistically significant (p＞0.05) Biochemical parameters (Electrolytes, Urea, Creatinine, RBC, Cholesterol and Enzymes) were not seriously affected though there were increases in the concentration or levels of some of them. This shows that monosodium glutamate has hepatoxicity and nephrotoxicity tendencies especially when consumed at higher concentrations.

並列關鍵字

Adult wister rats ； hepatoxicity ； monosodium glutamate ； nephrotoxicity ； serum biochemistry carcinogenic