The present study documents zootherapeutic practices in Kendrapara district, Orissa, India. It is primarily based on field surveys carried out in villages, where dwellers provided information on animal species used as medicine, body parts used to prepare the remedies, and the illnesses to which the remedies were prescribed. The animal parts, viz. blood, excreta, feather and horn were used in raw or cooked forms for the treatment of piles, asthma, skin diseases, dysentery and rheumatism. These zootherapeutical resources were used for the cure of 11 illnesses. This research will hopefully help in monitoring and management of ethnomedicinal animals and highlights their importance in maintaining ecosystem services which could be a valuable tool for better understanding the long-term effects of traditional knowledge in Kendrapara district of Orissa, India.