Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken

A. El-Mahmoudy ； M. E. Mahmoud ； K. Fararh ； M. Draid ； A. El-Magdoub ； S. Awidat

《British Journal of Pharmacology and Toxicology》 3卷3期 (2012/06) Pp. 135-139

並列摘要

The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken were used, the first two groups received 100 mg/kg and 200 mg/kg sulfadimidine, respectively, in drinking water; while the third group was left as control. Bursal samples were taken after 7 and 14 days of treatment and checked for MHC-II gene expression by RT-PCR technique. The obtained results demonstrate that oral administration of sulphadimidine inhibited the expression of MHC-II mRNA in bursal of Fabricius of broiler chicken in a dose and age dependent manner. This finding is of clinical importance as many farmers routinely add sulpha drugs to drinking water as a prophylactic measure against some infections; yet the data presented in this study doesn't recommend this managing behavior.

並列關鍵字

B-cells ； broiler chickens ； bursa of fabricius ； Major Histocompatibility Complex Class II (MHC-II) ； sulphadimidine