N-nitrosodimethylamine (NDMA), Liver Function Enzymes, Renal Function Parameters and Oxidative Stress Parameters: A Review

Usunobun Usunomena ； Adegbegi J. Ademuyiwa ； O. Okugbo Tinuade ； F. Evuen Uduenevwo ； Osibemhe Martin ； N.P. Okolie

《British Journal of Pharmacology and Toxicology》 3卷4期 (2012/08) Pp. 165-176

並列摘要

The aim of this study is to review a procarcinogen, the N-Nitrosodimethylamine (NDMA), liver and kidney functional enzymes (in assessing action of toxicants such as NDMA) as well as oxidative stress parameters (in assessing the extent of free radical damage and scavenging). Catalase and hydro peroxidase enzymes convert hydrogen peroxide and hydro peroxides to non-radical forms and functions as natural antioxidant in human body. Enzymes like Superoxide Dismutase (SOD) and Catalase (CAT) and compounds such as tocopherol and ascorbic acid can protect organisms against free radical damage. Lipid peroxidation is a mechanism generally recognized as being the most important in the pathogenesis of liver injury by a number of toxic compounds including NDMA.

並列關鍵字

Carcinogenesis ； CYP2E1 ； liver ； N-nitrosodimethylamine ； renal ； ROS