Analgesic, Anti-Inflammatory and Antipyretic Potential of the Stem Bark Extract of ＂Stachytarpheta indica＂

G.C. Akuodor ； A.D. Essien ； P.M. Udia ； David-Oku ； C. Chilaka ； E.C. Asika ； S.K. Nwadum

《British Journal of Pharmacology and Toxicology》 6卷1期 (2015/02) Pp. 16-21

並列摘要

Aim of study: Stachytarpheta indica is used as herbal remedy for pains in Nigeria. Methods: To validate this claim, the analgesic, anti-inflammatory and antipyretic effects of the stem bark extract were examined in mice and rats by using acetic acid-induced writhing, tail immersion, xylene and egg albumin-induced paw oedema. While yeast and amphetamine induced pyrexia were used to study antipyretic activity in rats. LD50 of the stem bark extract was carried out to determine its safety. Results: The methanol stem bark extract of Stachytarpheta indica showed significant (p＜0.05) dose dependent effect in the parameters assayed. The activity of the extract was comparable to greater than 5000 mg/kg. Conclusions: It may be possible that the methanol stem bark extract of Stachytarpheta indica contains biologically active substances with potential value for the treatment of painful and feverish conditions.

並列關鍵字

Herbal medicine ； inflammation ； nociception ； pyrexia ； rats ； Stachytarpheta indica