- 期刊
- OpenAccess
Sudden Onset of Blisters During Remisson from Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
在史蒂芬強生症候群／毒性表皮壞死溶解症患者的緩解期突然又產生水泡
摘要
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is an extensive, life-threatening, drug-induced skin eruption. Common sequelae among survivors are xerotic eczema and heat intolerance, but recurrent blisters during the remission period are rare. Here, we report a 65-year-old women who presented with multiple blisters during remission from SJS/TEN. Miliaria crystallina, a self-limiting disease, was eventually diagnosed after excluding many diseases, such as autoimmune bullous disease, herpes virus infection, bullous impetigo, transient acanyholytic dermatosis, and SJS/TEN recurrence. We show that blisters occurred because of eccrine duct disruption and fluid accumulation beneath the necrotic epidermis and that this presentation can mimic SJS/TEN. It is important to consider this self-limiting condition to avoid unnecessary worry and intervention.
並列摘要
史蒂文強生症候群/毒性表皮壞死溶解症是一個嚴重及可致死的藥物疹。常見的後遺症包括皮膚乾燥及熱耐受性不良。在史蒂文強生症候群/毒性表皮壞死溶解症的緩解期又反覆出現水泡是很少見的。我們報告一個65歲的女性在史蒂文強生症候群/毒性表皮壞死溶解症的緩解期又反覆出現水泡。在排除其他疾病，如自體免疫性水泡病，單純性皰疹，水泡型膿痂疹，暫時性棘皮鬆解皮膚病以及復發性史蒂文強生症候群/毒性表皮壞死溶解症後，診斷為一自限性的晶狀汗疹。我們的病例報告提醒在史蒂文強生症候群/毒性表皮壞死溶解症的患者上，因為汗腺管的破壞及體液堆積在壞死上皮之下會造成反覆的水泡發生。了解這是自限性且無害的情況是重要的，因可必免不必要的擔心和處置。