- 期刊
- OpenAccess
Acute Necrotizing Encephalopathy of Childhood with Novel Influenza A (swH_1) Infection: A Case Report
兒童急性壞死性腦病合併豬流感：一病例報告
摘要
Acute necrotizing encephalopathy of childhood (ANEC) is an extremely rare disease exclusively recorded in previously healthy infants and children. This disease has a broad clinical, radiological, and biochemical spectrum as well as high morbidity and mortality rates. Symmetric lesions in the thalami are the diagnostic hallmarks. We have reported here a previously healthy girl (age: 4 years and 8 months) who presented with intermittent fever and vomiting. She, very soon, developed generalized tonic seizures and rapid loss of consciousness. Cultures of her nasal swab specimen revealed swine influenza H1 (swH1) virus. Her brain imaging demonstrated the typical findings of ANEC. A combination of oseltamivir, immunoglobulins, and methylprednisolone were administered to her under supportive care, through which the patient survived.
並列摘要
兒童急性壞死性腦病（Acute Necrotizing Encephalopathy of Childhood; ANEC）是一種極為罕見而且只侵犯發病前很健康的嬰幼兒。此病有較廣泛多變的臨床表徵、放射線檢查與生化檢查，而且有極高的罹病率與死亡率。於視丘有對稱性的影像變化是此病的特色。我們報導一個在發病前是很健康的4歲8個月女童，她一開始以間歇性的發燒與嘔吐表現，隨著發生抽搐與快速的意識喪失，鼻腔病毒分離出豬流感，腦部影像學出現典型的兒童急性壞死性腦病的特徵。此女童在我們積極使用Oseltamivir、immunoglobulins和methylprednisolone存活下來。