- 期刊
The Influence of Both Tumor Necrosis Factor Α and Insulin-Like Growth Factor-1 Polymorphisms on Lean Muscle Mass in Community-Dwelling Elders in Taiwan-Taichung Community Health Study for Elders (Tchs-E)
並列摘要
Purpose: This study examined the influence of both tumor necrosis factor α (TNF-α) and insulin-like growth factor-1 (IGF-1) polymorphisms on lean muscle mass, by investigating six single-nucleotide polymorphisms (SNPs) of two genes in community-dwelling elders in Taiwan. Methods: Six polymorphisms of TNF-α (SNPs rs1799964 [S1], rs1800629 [S2], and rs3093662 [S3]) and IGF-1 (SNPs rs6214 [S4], rs5742692 [S5], and rs35767 [S6]) genes were examined in 472 participants (221 women and 251 men). Site-specific lean muscle mass (arms, legs, and trunk; kg), appendicular skeletal muscle mass (ASM; kg), and total body lean soft tissue mass (free-fat mass, FFM; kg) were measured by Dual-energy X-ray absorptiometry. Height-adjusted skeletal muscle index (hSMI; kg/m^2) was defined as ASM divided by height squared. Weightadjusted skeletal muscle index (wSMI; %) was tallied as ASM divided by weight. Results: The joint effects between TNF-α and IGF-1 polymorphisms included S1 & S5 and S1 & S6 with arm lean muscle mass in the women group, and included S3& S4, S3& S5 and S3 & S6 with 3 site-specific lean muscle mass (arms, legs, and trunk), FFM, ASM, hSMI and wSMI in the men group. In the women and men, in combination in TNF-α SNPs S1 & S2 and S1 & S3, were significant joint effects on lean muscle mass by adjusted age, BMI, smoking and physical activity. We received evidence of a statistical interaction between S4 and S6 at legs lean soft tissue mass in elderly women was significant (P ＜ .05). Conclusion: Our data show that an observed joint effect and interaction between TNF-α and IGF-1 polymorphisms on lean muscle mass in elders.