The number of sets in resistance training program which required to produce maximal strength gain were still controversial. We examined the changes in maximal strength between groups with different weight training workouts in the present study. 22 untrained young males were divided into three groups randomly, each group perform a different sets of weightlifting squats; the groups did one set, three sets, six sets, respectively; all groups used 8 repetitions at maximum weight, for each; all groups lifted weight two times per week, and the study lasted ten weeks. The 1 repetition maximum of each subject was tested at the beginning of the training period, at the 4(superscript th) week, the 7(superscript th) week and at the 10(superscript th) week. The result showed there were no significantly differences in 1 repetition maximum between the three groups after ten weeks of training. It could be conclude that, in untrained individuals, there were no difference in maximum strength, regardless of whether they practiced one set, or for multiple sets of exercises.