Stem-Cell-Derived Exosome Alleviates Hyperlipidemia in a Patient with Pectus Excavatum

A 46-year-old man received a diagnosis of pectus excavatum (PE), which was then corrected through surgery. After surgery, this patient still had chest pain and high triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels. To solve these problems, eight intravenous infusions of a stem-cell-derived exosome mixture (named TELOXOME) were conducted. In addition to achieving a moderate reduction in chest pain, the treatment significantly reduced the patient's TG, TC, and LDL levels. To our knowledge, this is the first case of a stem-cell-derived exosome reducing the pain of a patient with PE and improving their hyperlipemia. This result indicates that our exosome mixture (TELOXOME) is a potential regimen for the treatment of hyperlipidemia.

Keywords

exosome ； hyperlipemia ； hypertriglyceridemia ； hyperlipidemia ； triglyceride ； lipid metabolism ； TELOXOME

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