The Effect of Digoxin on Ovarian Cancer Cells

Ovarian cancer is a gynecological malignancy associated with a poor 5-year survival rate. High metastasis and late-stage diagnosis contribute to limited effectiveness of current therapies in ovarian cancer. Estrogen is known to stimulate the growth of ovarian cancer cells, particularly in patients with late-stage ovarian cancer and estrogen receptor alpha overexpression. Steroid hormones and their receptors are key therapeutic targets in ovarian cancer research. The present study highlighted that cardiac steroid glycosides digoxin, digitoxin, and ouabain inhibit cell proliferation and induce cytotoxicity in ovarian cancer cells. We investigated the effects of various concentrations of digoxin and digitoxin on SKOV-3 cells. The results suggest that digoxin, digitoxin, and ouabain have potential as antitumor agents in ovarian cancer.

Keywords

Ovarian Cancer ； Digoxin ； Digitoxin ； Oubain and SKOV-3

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