Against the background of a global outbreak caused by the new coronavirus, examine the epidemic situation as a global epidemic. Sort out the relevant disposal actions of the United States, Japan, South Korea when they facing the coronavirus disease 2019 (COVID-19). Integrating the biological disaster prevention and response plan of Taiwan's Central Government and Kinmen County Government. By sorting out the timeline of the epidemic response, study the countermeasure of the Kinmen County Government for no one is diagnosed in the outbreak nearly 10 months. Finally, this study summarizes the four key aspects of the response for the Kinmen County Government. The four key aspects are "strengthen entry and exit epidemic prevention control," "medical supplies and resources preparation," "strengthen home isolation control," and "cancel the large-scale events."