This case report describes a 37-year-old female patient with a medical history of uterine fibroids, mixed anxiety, and depression symptoms. She began experiencing frequent urination symptoms in November 2020, and was diagnosed with overactive bladder by the urology department. After more than two years of medication and electrical stimulation therapy, her symptoms continued to recur, leading her to seek treatment from traditional Chinese medicine (TCM). The TCM diagnosis identified urinary issues related to spleen and kidney deficiency, and the treatment approach focused on tonifying the spleen, nourishing the kidneys, and regulating liver function to alleviate depression. In this article, the author compiles both TCM and Western medicine theories regarding the urinary system, as well as recent treatment research, with the aim of providing insights into the treatment of such conditions.