- 期刊
中西藥對精神壓力型胃潰瘍療效之比較
The Comparison between Chinese and Modern Medicine on Peptic Ulcer by Physical Stress
摘要
The purpose of this study was to evaluate anti-peptic ulcer effects of SiJunZiTang (SJZT), BuZhonYiQiTang (BZYQT), Cimetidine and Ranitidine. In this study, Wistar rats (200±20g) and ICR mice (20±2g) had been used as the experimental materials. These animals were starved but allowed free access to water for at least 24 hours before medication. The experimental dosage of medicine was as follows: SJZT 500 mg/kg, BZYQT 500 mg/kg, Cimetidine 10mg/kg and Ranitidine 5 mg/kg, were given by p.o. (per os) and i.d. (duodenal-injection). Takagi's inundate limited method and Shay's pylorus ligation had been used to know the effects of medicine on free HCl in gastric juice and on the peristalsis function of small intestines. The results indicated that the peristalsis function of small intestines have no differences when compare SJZT, BZYQT, Cimetidine, and Ranitidine to normal saline controller group. When the incidence of ulcer by physical stress with 0.9% NaCl control group had been taken as 100%, incidences of four experimentation medicines were: SJZT 81.14% (p＜0.01), BZYQT 89.77%, Cimetidine 84.41%(p＜0.05) and Ranitidine 90.95%. By the results, Chinese medicine SJZT can lower gastric ulcer which induced by physical stress, and don’t affect the function of small intestines plexus. That makes SJZT merited to use on prevention of ulcer caused by physical stress.
並列摘要
The purpose of this study was to evaluate anti-peptic ulcer effects of SiJunZiTang (SJZT), BuZhonYiQiTang (BZYQT), Cimetidine and Ranitidine. In this study, Wistar rats (200±20g) and ICR mice (20±2g) had been used as the experimental materials. These animals were starved but allowed free access to water for at least 24 hours before medication. The experimental dosage of medicine was as follows: SJZT 500 mg/kg, BZYQT 500 mg/kg, Cimetidine 10mg/kg and Ranitidine 5 mg/kg, were given by p.o. (per os) and i.d. (duodenal-injection). Takagi's inundate limited method and Shay's pylorus ligation had been used to know the effects of medicine on free HCl in gastric juice and on the peristalsis function of small intestines. The results indicated that the peristalsis function of small intestines have no differences when compare SJZT, BZYQT, Cimetidine, and Ranitidine to normal saline controller group. When the incidence of ulcer by physical stress with 0.9% NaCl control group had been taken as 100%, incidences of four experimentation medicines were: SJZT 81.14% (p＜0.01), BZYQT 89.77%, Cimetidine 84.41%(p＜0.05) and Ranitidine 90.95%. By the results, Chinese medicine SJZT can lower gastric ulcer which induced by physical stress, and don’t affect the function of small intestines plexus. That makes SJZT merited to use on prevention of ulcer caused by physical stress.