Colon interposition has become a golden standard for treating patients with congenital or acquired both benign and malignant esophageal strictures. However, a variety of late complications have been reported, including anastomotic leak, anastomotic stricture, Gastro-colic reflux, and colon-graft stricture. Our case is about a seventy-four-year-old female undergoing esophageal reconstruction using colonic interposition for esophageal malignancy at her age of forty-one. The rare complication of an adenocarcinoma developing in the graft proved in the final histolopathology. The new onset of dysphagia after surgery is likely to be the contribution for the recurrent malignancy. As a result, we review the associated articles about complications of colon interposition and discuss the post-operative morbidity as a cause of recurrent dysphagia or other symptoms.