In this thesis, we proposed an ECG/EEG multi-signal system using mobile devices, we realized ECG/EEG signals capturing, long-time physiological monitoring, and then calculating the heart rate(R-R wave) and brainwave frequency (α, β, θ, δ wave). The system will auto determine the arrhythmia and brainwave status. Then, by use of mobile devices, we got the health conditions for a patient through 3G or Wi-Fi system. And then, the Electrocardiography (ECG) and Electroencephalography (EEG) signals were stored. Finally, we carry out a telemedicine system to prevent heart disease.