- 期刊
- OpenAccess
薑黃及薏仁對高脂高膽固醇飲食模式小鼠血液及肝臟脂質之影響
Effects of turmeric (Curcuma longa) and Job's tears (Coix lacryma-jobi) on Serum and Hepatic Lipid Profiles in Mice Fed with a High-fat-high-cholesterol Diet
摘要
薑黃（Curcuma longa）為中國及印度常見之傳統藥食兩用食材，其主成分薑黃素具有調節血脂、抗發炎、抗氧化、抑制腫瘤等效果，本研究探討薑黃及薑黃薏仁對調節血脂及抗脂肪肝之功效。動物試驗提供高脂高膽固醇飼料作為C57BL/6品系小鼠基礎飲食，試驗組分別為添加0.2%薑黃粉及以全穀紅薏仁（Coix lacryma-jobi var. Ma-yuen）取代20%高脂高膽固醇飼料再混入0.2%薑黃粉，並以辛伐他汀（simvastatin）藥物作為正對照組，正常飲食作為控制組，進行各組小鼠血液、肝臟脂質與肝腎功能評估。結果顯示，添加薑黃組與薑黃薏仁組皆可顯著抑制體重增加，改善高脂高膽固醇飼料導致的血漿三酸甘油酯，並改善高脂高膽固醇飼料造成的脂肪肝、肝臟總膽固醇、肝臟三酸甘油脂且降低肝臟重量。於腎臟功能指標部分，則可顯著降低血清中尿素氮的濃度。另外比較全穀紅薏仁的添加是否對薑黃改善代謝疾病各項指數有所助益，結果顯示兩者在改善血脂效果上並無明顯差異。整體而言，薑黃於本研究中具有降低血脂、改善脂肪肝之現象，具有可開發為降血脂及護肝健康食品之潛力。
並列摘要
Tumeric (Curcuma longa) is one of the traditional medicinal foods in China and India. Its main ingredient, curcumin, is recognized as the major functional compounds. Curcumin shown multiple functions such as ameliorating hyperlipidemia, anti-inflammatory, anti-oxidation, hepatic protection and anti-tumors. This study uses C57BL/6J mice fed with high fat high cholesterol diet (HFHCD) for 8 weeks to induce fatty liver, test materials were incorporated into HFHCD afterwards for another 12 weeks. The experiment consisted of two groups, supplementation of 0.2% turmeric powder (HFHCD-C), and whole grain Job's tear (Coix lacryma-jobi var. Ma-yuen) replaced 20% of HFHCD diet with 0.2% turmeric powder (HFHCD-CC), simvastatin was used as the positive control group. At the end of experiment, all mice were sacrificed to examine the effects of turmeric or turmeric-Job's tears on serum and hepatic lipids profiles. The results showed that mice fed with HFHCD were all induced hyperlipidemia and fatty liver. Both groups supplemented with turmeric (HFHCD-C), or turmeric-Job's tears (HFHCD-CC) could reduce body weight gain and liver weight significantly. The serum TG, hepatic TC, TG and the concentration of blood urea nitrogen was all reduced significantly. The addition of whole grain job's tear in diet could reduce food efficiency and total fat weight, while the lipids profiles did not differ significantly with turmeric group in this experiment. In conclusion, turmeric can ameliorate hyperlipidemia and fatty liver in this study. Turmeric showed great potential to be developed as a healthy food for hyperlipidemia and non-alcoholic fatty liver disease.