- 期刊
Recurrent Hepatic Sarcomatoid Carcinoma Cured by Doxorubicin and Ifosfamide Chemotherapy
復發性肝臟類肉瘤上皮癌經化學治療治癒
摘要
肝臟類肉瘤上皮癌是同時含有上皮癌和肉瘤兩種組成成分的一種罕見惡性腫瘤。與一般的肝細胞癌相比，這種腫瘤在根治性切除手術後有較高的復發和遠端轉移的風險。此外，目前對於患有轉移性肝臟類肉瘤上皮癌的患者並沒有有效的治療，因此預後很差。在此我們提出一位患有肝臟類肉瘤上皮癌的個案，雖然在手術後復發並合併淋巴轉移，但在化學治療後達到完全緩解。這位68歲女性被診斷有一個5.7公分肝腫瘤合併有肝門靜脈部分栓塞而接受肝右葉切除及膽囊切除。病理報告顯示肝臟類肉瘤上皮癌合併靜脈侵犯。手術後三個月的電腦斷層發現多顆肝內復發腫瘤。她隨後接受7個療程的doxorubicin合併ifosfamide化學治療而達到完全緩解並在那之後維持無病狀態。
並列摘要
Hepatic sarcomatoid carcinoma is a rare malignant neoplasm composed of both carcinomatous and sarcomatous components. It has a higher risk of relapse and distant metastasis compared with ordinary hepatocellular carcinoma despite of radical resection. To date, there is no effective treatment available for patients with metastatic hepatic sarcomatoid carcinoma, and their prognosis is extremely poor. We present a case of hepatic sarcomatoid carcinoma relapsing after surgical resection in which complete remission was achieved by chemotherapy. This 68 year-old female patient was diagnosed with a 5.7 cm liver tumor with partial portal vein thrombosis. She underwent right hepatic lobectomy and cholecystectomy. Pathology revealed hepatic sarcomatoid carcinoma with venous invasion. Multiple recurrent intrahepatic tumors and lymphadenopathies were found by CT scan 3 months after surgical resection. She received salvage chemotherapy consisting of seven cycles of doxorubicin and ifosfamide and achieved complete remission. She has remained disease free.