- 期刊
影響早期子宮頸腺癌及腺鱗癌預後之病理因子：臺北榮民總醫院10年經驗
Assessment of outcomes in patients with early-stage cervical adenocarcinoma and adenosquamous carcinoma:10-year experiences from Taipei Veterans General Hosital
並列摘要
Background: To investigate the prognostic factors and the impact of adjuvant therapy on survival in patients with early-stage cervical adenocarcinoma and adenosquamous carcinoma. Materials and methods: Patients with stage I-II cervical adenocarcinoma and adenosquamous carcinoma who underwent radical hysterectomy with pelvic lymphadenectomy and para-aortic lymph node sampling as a primary treatment at Taipei VGH from January 2001 through December 2011 were included in this study. The surgical-pathologic factors evaluated in this study include histology, grade of differentiation, primary tumor size, depth of stromal invasion, lymph-vascular space invasion, pelvic lymph nodal metastases, parametrium involvement and surgical margin. Results: All pelvic lymph nodal metastases, positive surgical margin, parametrium involvement, big tumor size, deep stromal invasion, and lymphvascular space invasion did not have effect on survival. Grade 3 differentiation had marginal effect on overall survival (p=0.05). Conclusions: The analysis of prognostic factors demonstrated that only grade of differentiation had effect on overall survival. There was no significant difference in survival in patients with adjuvant therapy after primary surgical treatment. Because of small sample size and retrospective study, we hope to have a randomized prospective study to give us more information.