Cancer cachexia is a syndrome characterized by weight loss accompanying loss of muscle and/or fat tissue wasting and induces to impaired patient function and physical performance and is associated with a poor prognosis. Multidisciplinary management of cancer cachexia has the potential to improve patient outcomes and efficiency of care. Multidisciplinary management consists primarily of exercise, nutrition and pharmacotherapy. The pharmacist's role in cancer cachexia is to contribute to appropriate pharmacotherapy practices, such as stimulating appetite and increasing food intake and body weight. Currently, there are no effective medical interventions to completely reverse cachexia. There is a need to develop a multimodal treatment approach combining pharmacology, exercise program, and nutritional support to target anorexia and the severe metabolic changes encountered in cancer cachexia.