- 期刊
富含猴頭素A的猴頭菇菌絲體於改善阿茲海默氏症的潛力
Erinacine A Isolated from Hericium Erinaceus Mycelia Shows Potential in the Improvement for Alzheimer's Disease
摘要
阿茲海默症（Alzheimer's disease）為最常見的神經退化性疾病，主要是患者的大腦皮質（cortex）和海馬迴（hippocampus）的神經細胞萎縮及死亡，進而導致記憶及認知能力喪失、語言與知覺功能退化。本研究利用液態發酵猴頭菇（Hericium erinaceus）菌絲體純化出猴頭素A（Erinacine A），並且在初代皮質細胞（primary cortical neurons）實驗中發現濃度50 μM的猴頭素A能顯著減少神經毒物Aβ（25－35）對神經細胞的傷害。對於五月齡阿茲海默模式（APP/PS1）小鼠中，發現腦腔注射（ICV）猴頭素A能增加小鼠大腦海馬迴神經細胞增生，同時在管餵30天的實驗中，發現不論是猴頭菇菌絲體、萃取物與猴頭素A均能有效刺激阿茲海默小鼠海馬迴神經細胞增生，結果可說明口服猴頭菇菌絲體具有改善阿茲海默氏症的潛力。
並列摘要
Alzheimer's disease is the most common neurodegenerative disease, mainly due to atrophy and death of nerve cells in the cerebral cortex and hippocampus. This defect leads to impairment of cognitive functions including memory, language, and perceptual abilities. In this study, we tested effects of erinacine A on neuronal cells. Erinacine A was extracted from fermented Hericium erinaceus mycelia and was found to significantly prevent Aβ (25-35)-induced apoptotic neuronal cell death in primary cortical neurons at a concentration of 50 μM. Utilizing a five-month- old Alzheimer's mouse model (APP/ PS1), we found that intracranial injection (ICV) of erinacine A resulted in increased number of hippocampal neurons in the mouse brain. Moreover, oral administration of Hericium erinaceus mycelia, Hericium erinaceus extract, or erinacine A enhanced hippocampal neurogenesis in these mice after 30 days of treatment. Based on these findings, we conclude that Hericium erinaceus mycelia can potentially be developed to aid the treatment of Alzheimer's disease.