- 期刊
複合益生菌菌顆粒對健康成年人腸道菌相（Microflora）的有益影響
Beneficial Effect of ＂Super 13 Pro & Prebiotics Lactic Acid Bacteria Granules＂ on Intestinal Microflora in Healthy Adults
摘要
本研究為評估“康爾喜N乳酸菌顆粒（Super 13 Pro & Prebiotics Lactic Acid Bacteria Granules）”（以下簡稱複合益生菌）對腸道菌相的影響。本產品由葡萄王生技股份有限公司（GRAPE KING BIO LTD）生產，含有以下細菌：Bifidobacterium lactis, B. bifidum, B. breve, B. longum, B. infantis, B. adolescentis, Lactobacillus acidophilus, L. casei, L. plantarum, L. rhamnosus, L. reuteri, Leuconostoc cremoris與Pediococcus pentosaceus。根據臺灣衛生福利部公佈的「健康食品之胃腸道功能改善評估方法（2003）」，招募了40個健康成人參加試驗，並隨機分配至實驗組和對照組，每組20名受試者。在為期4週的試驗期間，受試者每天服用複合益生菌，而對照組服用安慰劑。在第0、1、2、3和4週收集每個受試者的糞便，以培養法分析雙歧桿菌（Bifidobacterium spp.）、產氣莢膜梭菌（Clostridium perfringens）、乳桿菌（Lactobacillus spp.）及大腸桿菌群（coliform）的菌數。結果顯示，受試者服用複合益生菌2週後，其糞便中雙歧桿菌和乳酸菌的數量明顯高於對照組。在4週後，受試者糞便中雙歧桿菌與乳桿菌的數量分別比對照組高出2.981倍與5.607倍。試驗3週後，受試者糞便中的雙歧桿菌／產氣莢膜梭菌比值（B／C值）明顯高於對照組。總之，複合益生菌顯著地豐富好菌（雙歧桿菌和乳桿菌）數量，並減少壞菌（產氣莢膜梭菌）數量。綜合以上結果，本試驗結果顯示，市售複合益生菌顆粒產品具有增加腸內益生菌與調節腸道菌相的功能，對維護健康是有益的。
並列摘要
This study was conducted to evaluate the effect of the ＂Super 13 Pro & Prebiotics Lactic Acid Bacteria Granules＂ (referred to as complex probiotics hereafter) on intestinal microflora. This product is manufactured by GRAPE KING BIO LTD and contains the following bacteria: Bifidobacterium lactis, B. bifidum, B. breve, B. longum, B. infantis, B. adolescentis, Lactobacillus acidophilus, L. casei, L. plantarum, L. rhamnosus, L. reuteri, Leuconostoc cremoris, and Pediococcus pentosaceus. According to the ＂Methods for Evaluating the Improvement in Gastrointestinal Function by Healthy Foods (2003)＂ published by the Ministry of Health and Welfare of Taiwan, forty individuals were recruited and randomly assigned to experimental and control groups with 20 subjects in each group. In the 4-week trial period, experimental subjects were given the complex probiotics, and control subjects received placebo daily. Feces were collected from each subject and analyzed by bacterial culture at weeks 0, 1, 2, 3, and 4 for Bifidobacterium spp., Clostridium perfringens, Lactobacillus spp., and Coliforms Results showed that the number of Bifidobacterium and Lactobacillus in the feces of experimental subjects were significantly higher than in those of control subjects after 2 weeks of treatment. At the end of 4th week, the number of Bifidobacterium was 2.981-fold higher and that of Lactobacillus was 5.607-fold higher in the feces of experimental subjects than in those of control subjects. After 3 weeks of treatment, Bifidobacterium/Clostridium perfringens ratio (B/C value) of the experimental group was significantly higher than that of the control group. In summary, the complex probiotics significantly enriched the population of good bacteria such as Bifidobacterium and Lactobacillus and reduced the population of bad bacteria such as Clostridium perfringens. Taken together, results of this study suggest that the complex probiotics are beneficial to the maintena nce of a healthy intestinal flora.