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羊肚菌（Morchella spp.）菌絲體萃取物對糖尿病雄性大鼠生殖系統的影響
Effect of Morel Fungus (Morchella spp.) Mycelial Extracts on the Reproductive System of Diabetic Male Rats
Abstracts
本研究調查羊肚菌菌絲體萃取物對糖尿病大鼠生殖系統的保護作用。24隻雄性Sprague-Dawley大鼠被隨機分成四組，每組6隻。對照組大鼠食用正常食物4週，其他三組大鼠食用高脂肪食物3週，然後腹腔（IP）注射鏈脲佐菌素（streptozotocin）一次，劑量為30mg/kg，誘導大鼠患上第2型糖尿病。對照組大鼠腹腔（IP）注射相同體積的0.1mol/L檸檬酸緩衝液（citrate buffer, pH 4.5）。一週後，透過口服葡萄糖耐受試驗（oral glucose tolerance test）評估大鼠的糖尿病發展情況。對確診為糖尿病的大鼠分別以每天500 mg/kg B.W.的劑量管餵美味羊肚菌（Morchella esculenta, GKME）與六妹羊肚菌（Morchella sextelata, GKMS）菌絲體萃取物，為期4週。結果顯示，攝入GKME或GKMS菌絲體萃取物可有效緩解大鼠的高血糖（hyperglycemia）和高胰島素血症（hyperinsulinemia），維持睾丸形態，增加史托利細胞（Sertoli cell）與萊氏細胞（Leydig cell）數量，提高睾固酮（testosterone）含量，減少精子的氧化壓力（oxidative stress）。這些結果指出，GKME或GKMS菌絲體萃取物可改善精子健康和生育能力。
Parallel abstracts
In this study, the protective effect of Morchella spp. extracts on the reproductive system of diabetic rats was investigated. Twenty-four male Sprague-Dawley rats were randomly divided into four groups of 6 each. Rats in the control group were given normal diet for four weeks, while those in the other three groups were fed high-fat diet for three weeks and then induced to develop type 2 diabetes by intraperitoneal (IP) injection of streptozotocin once at 30 mg/ kg. Rats in the control group were IP injected with the same volume of 0.1 mol/L citrate buffer, pH 4.5. One week later, development of diabetes in the rats was assessed by oral glucose tolerance test. Rats with confirmed diabetes were each tube-fed with mycelium extracts of Morchella esculenta (GKME) or Morchella sextelata (GKMS) at a dose of 500 mg/kg B.W. per day for 4 weeks. Results showed that the intake of GKME or GKMS mycelium extracts effectively alleviated hyperglycemia and hyperinsulinemia, maintained testicular morphology, increased the number of Sertoli cells and Leydig cells and testosterone levels, and reduced oxidative stress on spermatozoa in rats. These results suggest that GKME or GKMS mycelium extracts could improve sperm health and fertility.