- 期刊
乙醯基輔酶A合成酶及其模擬化合物的介紹
Acetyl Coenzyme A Synthase and Complexes Related to Its Structure and Function
摘要
乙醯基輔酶A合成酶是其中一個以鎳金屬為主的金屬酵素，此酵素不管在結構上或是催化功能上在過去這幾年已經被廣泛的研究並建立。酵素中，鎳金屬所扮演的角色主要是催化乙醯基和輔酶A的反應而形成乙醯基輔酶A，且催化過程必須經過碳硫鍵的形成。科學家對乙醯基輔酶A合成酶之所以感到興趣是因為此酵素以特殊的金屬簇團作為活化中心和酵素進行催化時的反應機制，且乙醯基輔酶A合成酶催化的反應非常類似工業上Monsanto製造乙酸的製程。反應時，乙醯基輔酶A合成酶利用溫室氣體之一的二氧化碳當作反應物，是地球上重要的固碳作用之一。在模擬化合物的探討上，已有不少例子成功提供很多在結構上和催化功能性的支持和解釋。
並列摘要
One of nickel-based metalloenzymes, namely acetyl coenzyme A synthase (ACS) has been established in both structures and functions of the active site in the past years. Roles of nickel in this enzyme serve as catalytic centers to mediate the formation of C−S bond between the acetyl group and coenzyme A. The acetyl coenzyme A synthase system has attracted considerable attention since it provides an unique opportunity to study from its unusual metalloclusters (Acluster), the coupled reaction it catalyzes, similarity to the Monsanto acetic acid process, as well as its use of greenhouse gas CO_2 as a substrate. Indeed, model compounds related to acetyl coenzyme A synthase and various biophysical techniques have been lent to elucidate aspects of the structure and function of the Ni site in this enzyme.