- 期刊
以溶膠凝膠乳化技術製備新式物理化學複合防曬劑
A novel combined physical-chemical UV filter prepared by sol-gel/emulsion technique
摘要
本研究以先前之溶膠凝膠乳化技術之研究經驗，分別以甲氧基肉桂酸辛酯(Octyl Methoxycinnamate, OMC)/四乙基矽氧烷(Tetraethyl orthosilicate, TEOS)為0.5、1以及1.5添加，合成一個物理複合化學的新式防曬劑OMC/二氧化矽微膠囊(O-SMC)。探討改變比例對於粒徑、產率、包覆率以及載率的影響，改變添加比例對於粒徑並沒有影響。另一方面比例增加，載率也相對增加，但是產率及包覆率卻相對地降低。當OMC/TEOS為1.5時有最大載率30.88±0.73%，但產率(48.15±0.51 %)及包覆率(24.78± 0.86%)卻最低。綜合以上結果，得到當OMC/TEOS為1為最佳條件，平均粒徑為1183.22±33.53 nm(RSD值 2.83 %, n=3)，平均產率為57.92±0.27 %(RSD值0.47 %, n=3)。包覆率以及載率分別為32.64±0.55 %(RSD值1.68 %)及28.17±0.34%(RSD值1.21%, n=3)。防曬效果方面，添加O-SMC的防曬乳(SPF值20.21, Curve Area=109.15, UVA/UVB=0.23)，皆優於優於對照組SMC+OMC防曬乳(SPF值17.26, Curve Area=92.58, UVA/UVB=0.22)、二氧化鈦+OMC防曬乳(SPF值17.61, Curve Area=92.39, UVA/UVB=0.21)以及OMC防曬乳(SPF值15.63, Curve Area=100.93, UVA/UVB=0.16)。在安定性方面，經過紫外線315 J/cm2照射後，O-SMC防曬乳紫外線防護能力下降16.54%明顯優於對照組SMC+OMC防曬乳29.20%、二氧化鈦+OMC防曬乳28.46%以及OMC防曬乳35.25%。研究證明我們所合成的O-SMC能保護化學性防曬劑，且由於有一個可以做為物理性防曬的外殼提供了更高的紫外線防護能力。
並列摘要
In this study, OMC/silica microcapsules(O-SMC) , a novel physical-chemical UV filter were synthesized by sol-gel/emulsion technique. Respectively, Octyl methoxycinnamate (OMC) / Tetraethyl orthosilicate (TEOS) in the rate of 0.5, 1.0 and 1.5 were added. Results show no correlation between the OMC/TEOS ratio with size of microcapsule. Higher OMC/TEOS ratio resulting in higher capacity, but lower yield and entrapment sufficiency. When OMC/TEOS ratio equal to 1.5, microcapsule possess largest capacity 0.88±0.73 %, but with the lowest yield(48.15±0.51 %)and entrapment sufficiency (24.78± 0.86%) . With the optimum comdition(OMC/TEOS=1) to preparation of O-SMC. The average diameter is 1183.22±33.53 nm(RSD 2.83 %, n=3); and average yield rate is 57.92±0.27 %(RSD 0.47 %, n=3). entrapment sufficiency and capacity is 32.64 ± 0.55% (RSD 1.68%, n=3) and 28.17 ± 0.34% (RSD 1.21%, n=3). For sunscreen application, O-SMC sunscreen(SPF=20.21, Curve Area=109.15, UVA/UVB=0.23) is better than SMC+OMC sunscreen(SPF=17.26, Curve Area=92.58, UVA/UVB=0.22), TiO2+OMC sunscreen(SPF=17.26, Curve Area=92.39, UVA/UVB=0.21) and OMC sunscreen(SPF=15.63 , Curve Area=100.93 , UVA/UVB=0.16). The result of stability test shows, O-SMC sunscreen's UV protection only decrease 16.54% after UV(315 J/cm^2) irradiation, which is better than SMC+OMC-S(29.20%) , TiO_2+OMC-S(28.46%) and OMC-S(35.25%). Especially after UV(105 J/cm^2) irradiation OMC-S sunscreen's UV protection is significantly decrease 22.39%. Our studies shows, O-SMC can provide protective effect of chemical UV filter, and higher UV protection by it´s shell can be used as a physical UV filter.