Inhibitory effect of LY 255283 on the synthesis of leukotriene B_4 and thromboxane A_2 in human peripheral blood polymorphonuclear leukocytes and monocytes

M. Ugur ； M. Melli

《Mediators of Inflammation》 1993卷 (1992/12) Pp. 407-409

https://doi.org/10.1155/S0962935193000572

摘要

LY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)lHtetrazol- 5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B_4 (LTB_4) receptor antagonist, inhibited the production of LTB_4 in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187. In human monocytes activated by ionophore it inhibited also the production of thromboxane B_2 (TXB_2). The effect of LY 255283 on 5-lipoxygenase (5-LO) and LTA_4 hydrolase activities which catalyse the production of LTB_4 and LTA_4 has not been studied yet. It is thought that LY 255283 may inhibit the production of LTB_4 and TXA_2 by antagonising the effect of ionophore-induced LTB_4 on 5-lipoxygenase and cyclooxygenase in human peripheral blood PMNL and monocytes.

關鍵字

Human monocytes ； Human polymorphonuclear leukocytes (PMNL) ； Leukotriene B_4 (LTB_4) LY 255283 ； Thromboxane B_2 (TXB_2)