The effect of lipocortin 1 on neutrophil deformability

E. M. Drost ； W. MacNee ； S. F. Smith

《Mediators of Inflammation》 1996卷 (1996/12) Pp. 188-190

https://doi.org/10.1155/S0962935196000257

摘要

LIPOCORTN 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMIa’)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.

關鍵字

Deformability ； Lipocortin 1 ； Polymorphonuclear neutrophil