Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets

G. Valacchi ； Velio Bocci

《Mediators of Inflammation》 1999卷 (1999/12) Pp. 205-209

https://doi.org/10.1080/09629359990360

摘要

IN a previous work we have shown that heparin, in the presence of ozone (O_3), promotes a dose-dependent platelet aggregation, while after Ca^(2+) chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet components. We have here shown that indeed significantly higher amount of platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1) and interleukin-8(IL-8) are released in a dose-dependent manner after ozonation of heparinised platelet-rich plasma samples. These findings may explain the enhanced healing of torpid ulcers in patients with chronic limbischemia treated with O_3 autohaemoteraphy (O_3-AHT).

關鍵字

ozone ； platelets ； aggregation ； growth factors ； inteleukin-8