Azelastine and suplatast shorten the distribution half-life of IgE in rats

Kazuhiko Hanashiro ； Yoshihiro Tokeshi ； Toshiyuki Nakasone ； Masanori Sunagawa ； Mariko Nakamura ； Tadayoshi Kosugi

《Mediators of Inflammation》 2002卷 (2002/12) Pp. 61-64

https://doi.org/10.1080/096293501201170310

摘要

WE aim to clarify whether suplatast and azelastine (anti-allergic drugs) can shorten the half-life of immunoglobulin E (IgE) in the circulating blood. Thirty Wistar rats were divided into six groups. Distilled water or anti-allergic drugs were given orally for 6 day s after the first sensitization. Two milligrams of monoclonal dinitrophenyl (DNP) -specific rat IgE was administered to the rats, which had been given suplatast or azelastine orally. The level of DNP-specific rat IgE in the serum was estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of IgE was analyzed from its pharmacokinetic parameters. The elimination half-life of rat IgE was about 12 h irrespective of the sensitized state. The intercompartmental rate constants (K_(ct) and _(tc)) in the suplatast-administered or azelastine-administered group were larger than those of the distilled water-administered group under non-sensitized conditions. These findings suggested that the anti-allergic drugs used in the present study facilitated the ex cretion of IgE from the circulation in rats.

關鍵字

Anti-allergic drugs ； Turnover ； IgE ； Pharmacokinetics ； Rat