摘要
成人之主動脈瓣狹窄（aortic stenosis）是一種進行性的疾病，主動脈出口狹窄會造成左心輸出量下降，左心室慢性肥大，不可逆轉的心肌纖維化，最終導致心衰竭。目前，沒有藥物具有明確減慢主動脈狹窄惡化的作用，許多病人仍須使用介入性治療，包含：外科手術，或經導管主動脈瓣置換等方式進行治療，本文主要探討主動脈瓣之介紹與目前治療之發展。
參考文獻
O’Gara PT, Loscalzo J. Aortic Valve Disease, in Harrison's Principles of Internal Medicine, 20e, J.L. Jameson, et al. Editors. 2018, McGraw-Hill Education: New York, NY.
Jameson JL, et al. Valvular Heart Disease, in Harrison's Manual of Medicine, 20e. 2020, McGraw-Hill Education: New York, NY.
Eveborn GW., et al. The evolving epidemiology of valvular aortic stenosis. the Tromso study. Heart 2013;99:396-400.
Otto CM, et al. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation 1997;95:2262-70.
Thaden JJ, Nkomo VT, Enriquez-Sarano M. The Global Burden of Aortic Stenosis. Progress in Cardiovascular Diseases 2014;56:565-71.