- 期刊
- OpenAccess
Aurora Kinases in Head and Neck Squamous Cell Carcinoma
摘要
Background: Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. Overexpression and amplification of the Aurora-A and -B kinases lead to tumorigenesis, invasion and migration of cancer cells which would cause a worse clinical outcomes. Methods: A literature review. Results: The role of Aurora kinases in tumorigenesis has been gradually recognized. This review summarizes studies about Aurora kinases in recent years, including their biological function, relationship with oncogenesis, their inhibitors and the status of current trials about Aurora inhibitors aiming at head and neck squamous cell carcinoma (HNSCC). Conclusions: Overexpression of Aurora-A is associated with an aggressive tumor behavior and a poor survival in HNSCC. Aurora kinases have been regarded as a new target for cancer therapy although the development of Aurora kinase inhibitors for lots of clinical trials are undergoing, especially in the setting of combination therapy.