Depression is a prevalent symptom of dementia in the medium term, and it further accelerates the rate of social and cognitive decline. Past studies have pointed out that anti-dementia drugs and traditional Chinese medicine compound Ginseng Construction-Nourishing Decoction, can alleviate the symptoms of depression, and reduce the severity of dementia. Ginseng Construction-Nourishing Decoction both nourishing and soothing effects, indications include body weight loss, mental fatigue, easy to be frightened and so on. In this two-year follow-up study, we found that Ginseng Construction-Nourishing Decoction can enhance cognitive function and reduce depression, making clinical treatment an alternative.