At present, the operation of enterprises and government has been heavily implemented on network services. Consequently, great efficiency and convenience are obtained. This study presents a smart dentist registration management system for dental clinics based on the concept of mobile-commerce. The patient can do the appointment registration, booking and cancel the registration and so on conveniently using the APP in the smart phone. As the registered information has been stored the database system, nurses can easily use the back-end management system to manage patient information. In addition, for the intelligent automatic fill process of the cancellation of the registration, the system will find the appropriate patient to fill the vacancy based on his/her habitual treatment time and distance. This process can be done through the APP completely without human intervention. This enhances the great efficiency and reduces a lot of labor costs, but also greatly facilitates the patient registration matters.