Introduction: When the blood flow in the blood vessels of the systolic blood pressure (SBP) is higher than 130mmHg or the diastolic blood pressure (DBP) is higher than 80mmHg, it might be recognized as hypertension latent problem. Dizziness, headache and irritability are the most common symptoms of hypertension, which will cause inattention, memory loss, reduce work efficiency, and then easily derive occupational disaster problems. This study was to analyze the prevalence of hypertension among staffs in a Medical Centre of Southern Taiwan, and set up a corresponding health care strategy for help who had hypertension problem to control their blood pressure. Methods: Statistical samples of this study collected the blood pressure measurement data of employees worked at a Medical Centre of Southern Taiwan during 2012 to 2016. The Minitab v17 software was used as a tool to analyze the basic statistics and the prevalence of hypertension. In addition, the hypertension versus the relevant factors was demonstrated by the Chi-square test. Results: Study samples included 4496 cases and the average age was 37.0±11.0 years, of whom 25.1% were males with an average age of 40.5±12.2 years and women were 74.9% with an average age of 35.9±10.3 years. The mean blood systolic pressure in all samples was 117.5±13.5mmHg, and the diastolic blood pressure was 73.1±10.4mmHg, in which 41.5% were identified as abnormal blood pressure (20.2% were prehypertension and 21.3% were hypertension). Among the employees with hypertension, males (38.9%) were higher than females (15.3%). The Chi-square test showed that there was a statistically significant correlation between abnormal blood pressure versus gender, age, waist circumference, and BMI. Conclusion: High blood pressure may cause unexplained dizziness, upset or inattention, and thus affects the working efficiency. In this study, 41.5% employees in the hospital have abnormal blood pressure, which is worth the attention of health promotion management units. According to the analysis results, we formulate an appropriate health care strategy for 21.3% employees with hypertension to help them controlling blood pressure. The result of this study can be used as a reference for a hospital manager monitoring employee blood pressure abnormalities to prevent occupational safety problems.