Sit-to-stand performance is one key factor of independent living. Failure to perform sit-to-stand indicates a limited ability to participate in various important daily activities. Examining sit-to-stand performance helps effectively assess a patient's physical function. In this article, we reviewed the definition, stage, and key determinants of sit-to-stand and the methods of sit-to-stand evaluation to assist in detecting patients with potential risk of declined physical function in clinical setting. Rehabilitation training and modification of environment can then be provided to reduce the risk of disability.