As a student of Northrop Frye, the famous Canadian writer Margaret Atwood is deeply influenced by Frye's archetypal literary criticism. In her novel The Handmaid's Tale, she consciously uses many biblical archetypes, such as Gilead, Eye, Messiah, Handmaid. At the same time, she subtly rewrites these images so that they are far from their original meaning, but aid in expressing the main idea of the novel. Based on Frye's archetypal literary criticism, this paper analyzes Atwood's strategy of rewriting Biblical archetypes and points out that rewriting is not merely deconstruction and subversion. The author refuses to regard the Bible as a text that can produce a fixed meaning, and expresses her thoughts and anxieties about human destiny through Gilead's definitive interpretation of the Bible.