This paper studies the blending of East and West in Macau's urban architecture, and specifically describes how the Portuguese entered Macau by renting land. Since then, Portugal's influence on Macao's social life and other aspects has exceeded 400 years, and Macao has grown from a small fishing village to a city with a population of more than 600,000 people. The streets are crisscrossed with tall buildings. Macau architecture represents a tributary of the development of Oriental architecture. Many buildings have unique styles of Chinese and Portuguese architecture. The formation of Macao streets and the naming of streets condense the history and culture of more than 400 years, which is a specific explanation of Portuguese culture's contact and integration with the Oriental culture in Macao architecture, and to a certain extent reflects the development of Macao city and presents its unique cultural assets.