Expression and Prognosis Analyses of the FOXO Gene Family in Human Cancers

Jingwei Lin ； Bin Wang ； Hongfei Xi ； Yingdie Zhu ； Hongxing Shen

《World Scientific Research Journal》 6卷1期 (2020/01) Pp. 103-112

https://doi.org/10.6911/WSRJ.202001_6(1).0015

摘要

The investigation found that the FOXO gene family is involved in a variety of human cancers. This article focuses on the expression of several major cancers in humans. We conducted a detailed comparative analysis of the cancer group and the normal group. Through Oncomine database and Kaplan-Meier plotter, we observed that the mRNA expression levels of FOXO1and FOXO4 were decreased in most cancers compared with normal tissues. In survival analyses based on Kaplan-Meier Plotter, FOXO gene family except FOXO4 showed significant associations with survival outcome of different subtypes of breast cancer. In luminal A, high expression of FOXO1 or FOXO3 revealed better OS and RFS, inversely, in her2 enriched, low expression of FOXO6 showed better RFS and DMFS. Significant prognostic effects of the whole FOXO family were also found in lung adenocarcinoma. Especially, higher expression of FOXO1 or FOXO3 predicted better OS and FP, besides, the other members of FOXO gene family are also connected with OS. In addition, the expression level of the FOXO gene family is also associated with other cancers such as prostate and colorectal cancer. So we concluded some members of FOXO family could be prognostic biomarkers for defined cancer types.

參考文獻

Katoh, M., et al., Cancer genetics and genomics of human FOX family genes. 2013. 328(2): p. 198-206.

Brachène, A.C.D., J.B.J.C. Demoulin, and M.L.S. Cmls, FOXO transcription factors in cancer development and therapy. 2015. 73(6): p. 1159-1172.

Zhao, Y., et al., Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. 2010. 12(7): p. 665-75.

Ping, L., et al., A transcription-independent function of FOXO1 in inhibition of androgen-independent activation of the androgen receptor in prostate cancer cells. 2008. 68(24): p. 10290.

Shyam Babu, P., et al., Down Regulation of FOXO1 Promotes Cell Proliferation in Cervical Cancer. 2014. 5(8): p. 655.