This article takes the flood disaster in tongren, guizhou province as an example to understand the natural conditions and hydrogeology of the research area by consulting literatures and materials. Based on DEM data to determine the basin scope; Consult hydrological and meteorological data to analyze and simulate relevant parameters of the basin; Using the HEC-HMS module in WMS software, a combination of SCS curve method, SCS unit line method, and Muskingum method was used to establish a basin rainfall runoff model. The sensitivity of relevant parameters of the model was obtained by parameter sensitivity analysis in the study area, and then the parameters were calibrated. The parameters after the utilization rate was set were respectively used to simulate the rainfall-runoff intensity of the 24-hour rainstorm with a recurrence period of 20, 50 and 100 years. Then the simulated results of rainfall, runoff and flood peak flow in three different recurrence periods were input into SMS software for flood inundation simulation and flood disaster risk assessment during the recurrence period.