Decreasing of the Level of the Alzheimer's Amyloid β Peptide with the Ginseng Saponin Metabolite, Compound K

Yiming Liu

《World Scientific Research Journal》 6卷10期 (2020/10) Pp. 57-62

https://doi.org/10.6911/WSRJ.202010_6(10).0010

摘要

Alzheimer's disease is a common and serious progressive neurological disease that influences human beings. Previous study has shown that three kinds of specific ginsenosides, Rg1, Rg3, Re, are found to decrease the level of the toxic Alzheimer's amyloid β peptides, Aβ40 and Aβ42. This study investigates the effect of compound K, the ginseng saponin metabolite, on the level of Aβ40 and Aβ42 by using Culture Chinese hamster ovary 2B7 cells and three-to-four month old female mice. The possible results are treatment with increasing levels of compound K leads to increasing, decreasing, or the same levels of Aβ40 and Aβ42. The result of this study could lead to further investigation and discussion of the new, beneficial ginseng saponin metabolite. Future studies could focus on finding more functions of compound K and distinguishing the different effects between ginseng saponin metabolite and ginsenosides.

關鍵字

Amyloid β peptide ； Ginseng ； Compound K ； Rg1 ； Rg3 ； Re ； Ginsenosides

參考文獻

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