This paper focuses on the problems of high object labeling cost during the detection process of strongly supervised object detection and lower accuracy of the detection results of weakly supervised object detection. This paper proposes an object detection model based on weakly supervised learning, which combines domain transfer technology and the Continuation Multiple Instance Learning algorithm. First, the CycleGAN domain transfer technology is used to convert the source domain image dataset into comic, watercolor, and clipart three types of dataset images similar to the object domain image. Then, the feature extraction of object domain image is accomplished by C‐MIL algorithm, and obtains the instance label estimation through the two modules of instance selection and instance partition; finally, using the obtained domain transfer image and pseudo‐label annotation image to fine‐tune the pre‐trained object detector in turn. The experimental results show that, compared with the detection results of the weakly supervised object detection of domain transfer, the improved model has a higher average accuracy of the detection results of the three datasets.