MOG Antibody Positive Inflammatory Demyelinating Disease of Central Nervous System in 4 Cases and Literature Review

Yafei Song ； Ganqin Du ； Danyang Xu ； Xiaohui Yang

《World Scientific Research Journal》 7卷7期 (2021/07) Pp. 110-123

https://doi.org/10.6911/WSRJ.202107_7(7).0016

摘要

MOG-IgG associated disorders (MOGAD) are immune-mediated inflammatory demyelinating diseases of the central nervous system. The clinical manifestations include ON, myelitis, acute disseminated encephalomyelitis, brainstem encephalitis, etc. They are characterized by uniphase or recurrent course. It can lead to severe visual impairment, cognitive impairment, motor impairment, and bladder dysfunction. MOGAD is considered to be an independent disease entity distinct from Neuromyelitis Optica Spectrum Disorders (NMOSD), atypical multiple sclerosis, and acute dissemated encephalomyelitis. Myelin oligodendrocyte glycoprotein (MOG) antibody, aquaporin-4 (AQP-4) antibody, oligoclonal bands (OCB) and antibodies against autoimmune thyroid diseases is rarely reported. This paper reports the clinical characteristics of 4 patients with central nervous system inflammatory demyelinating disease with positive serum MOG antibodies admitted to the First Affiliated Hospital of Henan University of Science and Technology as follows, and reviews them in combination with relevant literature.

關鍵字

Myelin oligodendrocyte glycoprotein ； Neuromyelitis optica spectrum disorders ； Demyelinating disease ； Case reports

參考文獻

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